All it needs is some good tissue cleaning.
Experts from Scripps Research developed a new cleaning method that allows large biological samples to turn transparent. As to the importance of having that kind of opacity for samples, it turns out that this would make it easier for scientists to visualize and study biological processes occurring across multiple organ systems.
According to the study’s senior author, Li Ye, PhD, the method is a “simple and universal tissue-clearing technique for studies of large body parts or even entire animals.”
The new method uses a combination of organic solvents and water-based detergents, which can be used in an ordinary lab. For protecting the molecules within the tissue during the cleaning processes, water-based hydrogels will be used. “In many cases, you can just put the whole thing in a jar and keep it in a shaker on your benchtop until it’s done,” said co-first author Victoria Nudell. “This makes it practical and scalable enough for routine use.”
Image credit: Ye et.al
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